Our body produces nitric oxide naturally, essential for maintaining our blood vessel health. It can help us increase the blood flow in our body and reduce high blood pressure.

Hence, those supplements that can increase nitric oxide production may benefit us in managing our various health conditions. Nitric Oxide supplement is a dietary supplement that contains two essential amino acids, arginine, and citrulline, that can boost nitric oxide levels in our body.

Since the market is packed with many nitric oxide supplements, it might get confusing for us to choose the best one. Hence, our research and editorial team has curated a list of the best nitric oxide supplements that can outweigh the others in terms of quality and efficiency.

The Top Best Nitric Oxide Supplements To Improve Blood Flow

We will discuss the top 15 best nitric oxide supplements available. They have been ranked according to their efficiency in boosting nitric oxide levels, ingredients, pricing, and other significant criteria.

  • CrazyBulk NO2-Max
  • VigRX Nitric Oxide
  • The 20 Flow
  • Magnify Nitric Oxide Boosting Supplements
  • Transparent Labs Nitric Oxide
  • Sovereignty Purpose Nitric Oxide Pills
  • Siberian Green Rasputin Herbs Nitric Oxide Pills
  • Onnit Total Nitric Oxide Booster
  • Cellucor NO3 Chrome
  • Brutal Force IBUTALEAN
  • NitriLean
  • Brutal Force CARDALEAN Nitric Oxide Supplement
  • Juvenon BloodFlow-7 Nitric Oxide Booster
  • Old School Labs Vintage Burst
  • Snap Supplements Nitric Oxide Booster

CrazyBulk NO2 Max

  • Key Ingredients: Calcium, L-Arginine, Stearic acid, etc.
  • Money-Back Guarantee: 60-day money-back guarantee
  • Pricing: Starts at $69.99
  • What Makes It Stand Out: It is a premium and potent nitric oxide booster formulated to enhance blood flow, specially designed for workouts.

CrazyBulk NO2 Max is a renowned nitric oxide supplement brand in the market. It’s in high demand due to its efficiency in boosting nitric oxide levels naturally. Specially designed for people performing extensive workouts, it can be used for strength, endurance, enhanced performance, and energy.

CrazyBulk produces NO2 Max and includes many potent ingredients, including the two essential amino acids. Like most nitric oxide supplements, it enhances blood flow and circulation of oxygen in our bodies during workouts by promoting natural nitric oxide levels to the highest.

How Does CrazyBulk NO2 Supplement Help In Boosting Nitric Oxide Production?

Nitric-Max works to increase nitric oxide levels naturally. This dietary supplement is a potent vasodilator that can effortlessly widen and relax our blood vessels. This leads to more oxygen, blood, and essential muscle nutrients during extensive exercise.

As a result, our body receives increased stamina and strength to push our workouts to the max. Moreover, we can also experience long-lasting pumps as glucose and oxygen are getting delivered more rapidly to our muscles by using this nitric oxide supplement. We may delay fatigue and can also recover quickly to perform even better.

VigRX Nitric Oxide Boosters

  • Key Ingredients: L-Citrulline and L-Arginine.
  • Money-Back Guarantee: 67-day money-back guarantee.
  • Pricing: It starts at $59.95/bottle
  • What Makes It Stand Out: One of the best nitric oxide supplements to help boost male performance and drive.

VigRX Nitric Oxide is a dietary supplement developed by Nobel Prize-winning researchers who discovered the importance of nitric oxide in the body. Their discoveries revealed the extent of nitric oxide on blood sugar, blood pressure, cholesterol, and cardiovascular and immune health.

VigRX Nitric Oxide supplement boosts nitric oxide levels in our entire body 24X7 so that we always feel connected and perform whenever we’re ready. This supplement can quickly produce strong and long-lasting emissions without stimulants.

How Does VigRX Nitric Oxide Work In Boosting Nitric Oxide Production?

We lose about 85% of our ability to produce nitric oxide with age. Due to this, we have weak, droopy emissions, loss of morning wood, and various issues related to the male drive. VigRX Nitric Oxide helps boost nitric oxide levels in the body due to the presence of essential nutrients, vitamins, and amino acids.

The increased amount of NO can relax and dilate our blood vessels improving blood flow and reducing high blood pressure. More nitric oxide production can increase blood flow to male organs and enhance sex drive and performance.

Apart from that, VigRX Nitric Oxide also keeps our cholesterol, blood pressure, blood sugar, and other health concerns in check.

The 20 Flow

  • Key Ingredients: L-Citrulline, Vitamin C, Pinus Pinaster, etc.
  • Money-Back Guarantee: 365-day money-back guarantee
  • Pricing: It starts at $28.45
  • What Makes It Stand Out: This nitric oxide supplement contains natural ingredients that focus on nutrients for healthy blood flow.

The 20 produces a unique nitric oxide supplement named FLOW that follows modern formulas based on the 80/20 rule. This means our body will experience an 80% increase in nitric oxide production with only 20% of the ingredients used.

FLOW Nitric Oxide Booster is one of the best nitric oxide supplements formulated from organic vegetables and fruits. This supplement can regulate blood flow and support healthy blood pressure. Besides, this NO supplement can also improve memory, energy, oxygen circulation, lubrication, and bedroom performance.

How Does The 20 Flow Work In Increasing Nitric Oxide Levels?

The 20 Flow makers believe that what we put in our bodies matters greatly. This nitric oxide boosting supplement contains amino acids derived from organic watermelon and spinach to increase NO production. It can stimulate blood flow better than other nitric oxide supplements.

FLOW Nitric Oxide Booster is free of gluten, lactose, sugar, and other harmful substances. This formula supports two nitric oxide pathways in our body for dual benefits. It also supports the production of NO in our endothelial and salivary systems. Thus, keeping our arteries flexible and helping to prevent plaque buildup in them.

Moreover, it contains amino acid compounds and Vitamin C, which help increase citrulline absorption and promote the widening of our blood vessels.

Magnify Nitric Oxide Boosting Supplements

  • Key Ingredients: L-arginine, Beetroot extract, L-citrulline, Green coffee bean extract, turmeric root, etc.
  • Money-Back Guarantee: 14-day money-back guarantee
  • Pricing: It starts at $44.95
  • What Makes It Stand Out: An advanced Nitric oxide formula supports appropriately widening blood vessels during workouts.

Magnify Nitric Oxide Booster uses scientifically-backed ingredients to deliver healthy vasodilation and intense muscle pumps for extreme workouts. Their nitric oxide pills can help individuals get the most out of any activity without fatigue.

This dietary nitrate supplementation is one of those nitric oxide supplements that doesn’t contain GMOs or other harmful chemicals to help protect overall health. Manufactured in an FDA-restricted facility, Magnify Nitric Oxide Booster has undergone many clinical trials to check its efficacy in promoting nitric oxide production and improving blood flow.

How Does Magnify Nitric Oxide Work In Increasing Blood Flow?

Magnify Nitric Oxide supplement follows a simple mechanism. This supplement can increase nitric oxide production 20 to 30 minutes before the workout. Thus, impacting muscle pumps and vascularity.

When there is a good amount of NO in our body, our blood vessels naturally start widening and relaxing efficiently, pumping more blood to the areas of the body lacking nutrients and oxygen. The natural blood flow process is supported by the active ingredients in Magnify Nitric Oxide, proving to be a good supplement for overall health.

Transparent Labs Nitric Oxide

  • Key Ingredients: Vitamin C, L-arginine nitrate, Pine bark extract, Panax Ginseng, etc.
  • Money-Back Guarantee: 30-day money-back guarantee
  • Pricing: It starts at $44.99
  • What Makes It Stand Out: It is a clinically dosed nitric oxide activator containing hyperemic ingredients to boost nitric oxide production.

Transparent Labs Nitric Oxide is the best NO supplement on the market. It constitutes scientifically backed ingredients in the correct dosage that are clinically proven for its sterile, strict, safe, and efficiency standards.

In addition, Transparent Labs Nitric Oxide doesn’t contain any artificial coloring, sweeteners, or preservatives to provide optimum health support without any side effects.

The formula of Transparent Labs Nitric Oxide features many patented ingredients along with Vitamin C to boost nitric oxide production. Although it also contains naturally produced nuts, the company has an allergen control program that cleans its equipment between allergen and non-allergen runs!

How Does Transparent Labs Nitric Oxide Work In Boosting Nitric Oxide Levels?

The nitric oxide-boosting ingredients in Transparent Labs Nitric Oxide supplement contain essential amino acids that serve as nitrate substrates and donors for nitric oxide synthase. During intense training, these ingredients work rapidly to help provide robust blood flow to skeletal muscle tissue by boosting optimum nitric oxide levels.

Apart from that, Transparent Labs Nitric Oxide contains an endogenous antioxidant that helps eliminate oxidative stress and free radicals in the body. Thereby supporting healthy blood flow and blood vessel health.

Moreover, Transparent Labs Nitric Oxide also contains Vitamin C to create a synergistic effect, supporting our immunity, nervous and cardiovascular systems.

Sovereignty Purpose Nitric Oxide Pills

  • Key Ingredients: CoffeeBerry, Ashwagandha, S7, Cordyceps, Sun-theanine, Beetroot extract, etc.
  • Serving Per Container: 25 servings
  • Pricing: It starts at $69
  • What Makes It Stand Out: It is the best nitric oxide supplement that helps diminish anxiety, stress, and low energy while helping produce it naturally.

Sovereignty Purpose is a revolutionary and potent nitric oxide supplement formulated in powder form to transform our health inside and out. It contains natural ingredients derived from whole plants and herbs clinically proven to help lower blood pressure and blood sugar.

The Sovereignty Purpose nitric oxide formula contains 100% organic elements: soy-free, sugar-free, gluten-free, and GMO-free. Manufactured in an FDA-restricted facility, manufacturers of nitric oxide supplements claim that they can be used without a doctor’s prescription.

How Does Sovereignty Purpose Work To Boost Nitric Oxide Levels?

Sovereignty Purpose is jammed with nitric oxide-boosting ingredients that naturally boost NO production. As a result, this dietary supplement can enhance energy levels by stimulating the adrenal hormones. Moreover, it is reviewed as one of the best nitric oxide supplements to help improve blood flow and reduce high blood pressure.

In addition, Sovereignty Purpose features adaptogens that can revitalize our body and brain by diminishing free radicals in the body. Without free radicals and oxidative stress, this nitric oxide supplement works perfectly in helping reduce stress and anxiety.

Siberian Green Rasputin Herbs Nitric Oxide Pills

  • Key Ingredients: Horny goat extract, Maca root powder, L-arginine, Saw palmetto, etc.
  • Money-Back Guarantee: 30-day money-back guarantee
  • Pricing: It starts at $15.95
  • What Makes It Stand Out: It is a traditional Siberian formula to reduce high blood pressure and support men’s health, stamina, and strength.

Rasputin Herbs is a nitric oxide boosting supplement manufactured by a renowned company Siberian Green. The supplement’s ingredients are 100% organic, inspired by the recipe of a mystic healer of the Russian Imperial Family.

Siberian Green Rasputin Herbs contain horny goat extract that helps provide enhanced nitric oxide levels. It is manufactured in a GMP-certified facility in the USA and claimed to have no toxic chemicals. Specially designed for men, the components of this cardiovascular health nitric oxide supplement can help them gain unprecedented strength and stamina.

How Do Siberian Green Rasputin Herbs Work In Increasing Nitric Oxide Production?

The Siberian Green Rasputin Herbs formula contains a secret ingredient Epimedium, which is known to boost nitric oxide levels in the body to improve blood flow and oxygen circulation. As a result, our body tissues and muscles receive essential nutrition to support the overall body and mental stamina.

This natural Nitric oxide booster contains amino acids to revitalize our body and simultaneously focus mood and male drive. The makers of Siberian Green Rasputin Herbs recommend using this nitric oxide supplement 1 to 2 hours before physical activity to increase blood flow and facilitate improved blood circulation.

Proper blood circulation is necessary during prolonged physical activities as it gives us optimum energy levels to continue our intense workout without fatigue.

Onnit Total Nitric Oxide Booster

  • Key Ingredients: L-arginine and L-citrulline, mango fruit powder, grape seed extract, etc.
  • Money-Back Guarantee: 90-day money-back guarantee
  • Pricing: It starts at $39.99
  • What Makes It Stand Out: One of the most preferred and best nitric oxide boosters that come in powder form to support our body’s natural nitric oxide production.

Onnit Total Nitric Oxide promotes performance, muscle growth, and recovery by naturally supporting our body’s nitric oxide production. The makers state that, unlike other nitric oxide supplements, this works best due to its ability to produce optimum NO levels.

Onnit Total Nitric Oxide has been manufactured in an FDA-restricted facility and is clinically tested and tried to be effective and safe for consumption. This best nitric oxide pill does not contain caffeine or other stimulants which don’t cause any habit. The main aim of Onnit Total Nitric Oxide is to help individuals get the most out of their workouts.

How Does Onnit Total Nitric Oxide Work In Supporting Nitric Oxide Production?

The working mechanism of the Onnit Total Nitric Oxide formulation is simple yet effective. It helps our body improve low nitric oxide levels with two amino acids.

As a result, Onnit Total Nitric Oxide ingredients can widen the blood vessels, promoting more blood flow throughout the body and preventing any blood circulation restrictions.

Onnit Total Nitric Oxide helps individuals shift to higher gear during intense workouts by ensuring that our muscles get enough oxygen and nutrients. It also helps remove excess nutrients so our body doesn’t tire quickly.

Onnit Total Nitric Oxide manufacturers recommend users consume it regularly to support cellular integrity and cardiovascular health.

Cellucor NO3 Chrome

  • Key Ingredients: Vitamin C, L-arginine nitrate, and others
  • Money-Back Guarantee: 60-day money-back guarantee
  • Pricing: It starts at $23.09
  • What Makes It Stand Out: One of the best nitric oxide supplements is stimulant-free to improve blood flow and provide powerful pumps.

Cellucor NO3 Chrome has been raising the bar regarding the best nitric oxide supplements. According to the reviews, it is a powerful dietary supplement that gives individuals those extra few seconds during intense exercises to get ahead of others.

Cellucor NO3 Chrome features patented ingredients and nitrate technologies that have been clinically tested to be safe, pure, and effective. Since it is a stimulant-free formula, it can be included in morning or evening training. The makers of these nitric oxide pills recommend adding them to a healthy diet to amplify their results.

How Does Cellucor NO3 Chrome Work To Enhance Nitric Oxide Production?

Cellucor NO3 Chrome works to improve nitric oxide production in the body due to the presence of essential ingredients, such as amino acid compounds. These nitric oxide-boosting ingredients also feature Extreme Vascularity Complex, which has been clinically tested to increase blood flow and reduce low blood pressure.

The Extreme Vascularity Complex of Cellucor NO3 Chrome helps dilate our blood vessels during extensive workouts. As a result, our muscles get sufficient oxygen and nutrients that drive optimum performance, strength, recovery, and stamina.

Brutal Force IBUTALEAN

  • Key Ingredients: Maca root powder, L-arginine, etc.
  • Money-Back Guarantee: 100-day money-back guarantee
  • Pricing: It starts at $59.99
  • What Makes It Stand Out: It is a potent nitric oxide supplement that can take our muscle game to a new level and improve lower blood pressure.

Brutal Force IBUTALEAN is one of the best nitric oxide supplements on the market that provides many nitric oxide benefits and delivers unbeatable muscle growth. IBUTALEAN, having all the anabolic effects, is clinically proven safe and free of harmful components. Hence, it acts as a legal SARMs alternative.

The ingredients in Brutal Force IBUTALEAN are proven 100% safe to produce lean muscle growth and diminish muscle recovery times. It also supports the body’s natural healing process to help us come back bigger and stronger.

How Does Brutal Force IBUTALEAN Work?

Brutal Force IBUTALEAN promotes nitric oxide production in our body, which regulates blood flow to various tissues and muscles. With a good amount of blood pressure, our muscles receive sufficient oxygen and nutrients, which, in turn, helps burn fat and promotes lean muscle mass.

This supplement’s high nitric oxide levels increase blood flow, supporting muscle healing and endurance. Besides, IBUTALEAN delivers highly refined and potent amino acid compounds that stimulate the production of human growth hormones (HGH), which are essential for muscle growth.


  • Key Ingredients: Beet root extract, L-citrulline, Hawthorn extract, etc.
  • Money-Back Guarantee: 60-day money-back guarantee
  • Pricing: It starts at $49
  • What Makes It Stand Out: A popular natural nitric oxide supplement that supports fat-burning and promotes weight loss.

NitriLean contains vitamins, minerals, amino acids, and herbs blended safely to help produce nitric oxide and various human growth hormones. As a result, it is a potent nitric oxide pill to help individuals burn fat effectively.

This weight loss formula is manufactured in an FDA-approved facility and is vegan-friendly, free of soy, dairy, and GMOs. The manufacturers of NitriLean claim that users can include these nitric oxide supplements with a healthy diet and that intense workouts would not be required to lose weight.

How Does NitriLean Work?

NitriLean works to target the root cause of excess fat in our bodies. Since it boosts the production of nitric oxide, an essential chemical for burning fat, our blood vessels and muscles relax naturally. This mechanism, known as vasodilation, helps improve blood circulation.

As a result, our body starts losing excess fat with the help of NitriLean, which provides sufficient nutrients and oxygen to the blood. Simultaneously, it also helps reduce blood pressure and improve metabolic rate.

Many users have also claimed that NitriLean nitric oxide supplementation has improved the functioning of blood vessels, preventing diseases related to blocked blood vessels.

Brutal Force CARDALEAN Nitric Oxide Supplement

  • Key Ingredients: Ginseng extract, L-arginine, L-citrulline, etc.
  • Money-Back Guarantee: 100-day money-back guarantee
  • Pricing: It starts at $59.99
  • What Makes It Stand Out: It is a fat burner and endurance enhancer nitric oxide supplement to promote healthy blood flow.

Brutal Force CARDALEAN is one of the most preferred nitric oxide supplements for aiding lean muscle growth and increasing endurance. This dietary supplement is manufactured in an FDA+GMP-certified facility to ensure optimum safety standards.

The company uses 100% safe and natural ingredients to produce Brutal Force CARDALEAN, which helps accelerate fat burning. Unlike the other Cardarine supplements available in the market, it is a safe SARM alternative specially designed for bodybuilders to promote extreme vascularity.

How Does Brutal Force CARDALEAN Work?

Brutal Force CARDALEAN is jam-packed with essential amino acids that play an important role in promoting the healthy metabolism of our body to stimulate the fat-burning process. Along with that, it also has nitric oxide-boosting ingredients that support proper blood flow in our bodies.

It does that by reducing blood pressure and supporting the vasodilation function in the body. Brutal Force CARDALEAN ingredients can increase nitric oxide in the human body, widening and relaxing our blood vessels.

As a result, the blood flow to the muscles increases, delivering more nutrients and oxygen. Thus, allowing us to train harder, passively, reducing excess fat from our bodies.

Juvenon BloodFlow-7 Nitric Oxide Booster

  • Key Ingredients: L-arginine, L-citrulline, beetroot extract, green tea leaf extract, turmeric root, etc.
  • Money-Back Guarantee: 60-day money-back guarantee
  • Pricing: It starts at $39.95
  • What Makes It Stand Out: One of the most potent nitric oxide supplements on the market to promote nitric oxide production.

Juvenon BloodFlow-7 Nitric Oxide Booster is the best nitric oxide supplement formulated to target nitric oxide levels in the body naturally and safely. According to the manufacturers, it contains essential nutrients, Vitamin C, amino acids, and other minerals that can boost nitric oxide in our body up to 230%. Thus, providing optimum levels of energy and stamina.

Dr. Darren Farnesi, Medical Director of California’s Medical Age Management, created Juvenon BloodFlow-7. He has 24 years of experience making functional and regenerative medicine, which he used while creating this nitric oxide booster.

How Do Juvenon BloodFlow-7 Nitric Oxide Supplements Help In Increasing Nitric Oxide Levels?

Our body has low nitric oxide levels due to past injuries, plaque buildup, narrowed blood vessels, swelling, etc. Juvenon BloodFlow-7 Nitric Oxide Booster satisfies our bodies’ nitric oxide requirements. The supplement helps blood vessels expand to produce more nitric oxide.

As a result, our blood vessels can get enough nutrients and oxygen, helping prevent cardiovascular disease and heart disease while helping increase blood flow. It also consists of essential amino acid components that can help the proper circulation of blood in our body. This, in turn, can increase stamina and improve brain and immunity health.

Old School Labs Vintage Burst

  • Key Ingredients: L-arginine HCL, Maca root extract, Garlic concentrate, Green tea extract, Apple extract, etc.
  • Money-Back Guarantee: 100% money-back guarantee
  • Pricing: It starts at $49.99
  • What Makes It Stand Out: It is one of the best nitric oxide boosters that claim to boost NO naturally for 3 hours by increasing blood flow.

Old School Labs Vintage Burst is a specially formulated nitric oxide booster that can elevate NO levels for hours. Thus, enabling our bodies to have better and bigger pumps.

Many Vintage Burst users have claimed that this is one of the best nitric oxide supplements, enabling them to get into higher-intensity workouts. The ingredients present in this dietary supplement are clinically proven to maintain their quality and potency standards.

How Does Old School Labs Vintage Burst Work?

Vintage Burst, created by Old School Labs, balances our blood pressure levels by promoting healthy blood flow. As it supports nitric oxide production in our blood vessels, they can easily widen and relax for pumping essential oxygen and nutrients to the muscles.

We can show immense strength and endurance during intense workouts with proper blood flow and low blood pressure. Vintage Burst also works to boost our stamina and overall health.

Snap Supplements Nitric Oxide Booster

  • Key Ingredients: L-arginine, Vitamin B3, Ginseng root, Tribulus Terrestris, Amino Acids, Muira Puama, etc.
  • Serving Per Container: 45 servings
  • Pricing: Starts at $27.95
  • What Makes It Stand Out: It is one of the best nitric oxide boosters formulated with botanicals and amino acids to promote blood circulation.

Snap Supplements Nitric Oxide Booster contains 100 % safe ingredients that promote stamina and support cardiovascular and heart health.

This potent nitric oxide supplement can act as an effective pre-workout supplement and can produce immense strength and endurance if taken 30 minutes before the workout.

How Does Snap Supplements Nitric Oxide Booster Work?

One of the primary ingredients used in Snap Supplements Nitric Oxide is Muira Puama Bark Extract which has been proven to provide natural energy to the body. Besides, it contains essential natural amino acids that are potent components to boost nitric oxide production.

These compounds can help optimize nutrient delivery and oxygenation to the body. As a result, Snap Supplements Nitric Oxide Booster can support healthy blood flow, cardiovascular function, and health.

Variables to Consider Before Taking a Nitric Oxide Booster

Nitric oxide boosters have become increasingly popular among athletes and fitness enthusiasts to enhance performance and increase energy levels. However, several variables must be considered before taking a nitric oxide booster to ensure it is safe and effective.

Medical Conditions and Concomitant Medications

Before taking a nitric oxide booster, it is essential to consider any medical conditions you may have and any medications you are currently taking. Nitric oxide boosters can interact with certain medications, such as blood pressure medications, and may exacerbate certain medical conditions, such as asthma or kidney disease. It is essential to consult with your healthcare provider before beginning a nitric oxide booster regimen to ensure it is safe.

Exercise Performance Goals

Nitric oxide boosters are also marketed to increase energy levels and reduce fatigue. A nitric oxide booster may be worth considering if you struggle with low energy levels during exercise or throughout the day. However, it is essential to remember that nitric oxide boosters’ effects on energy levels may vary from person to person.

Energy Levels Safety and Side Effects of Nitric Oxide Boosters

Finally, it is essential to consider nitric oxide boosters’ safety and potential side effects. While generally considered safe for healthy individuals, some may experience side effects like headaches, nausea, or stomach upset. It is also essential to purchase a high-quality nitric oxide booster from a reputable source to minimize the risk of contamination or other safety concerns.

The Factors Considered While Ranking The Best Nitric Oxide Supplements

We have mentioned below all the ranking criteria we gave due consideration to while creating a list of the best nitric oxide supplements available in the market:

Ingredients That Are Backed By Science

When buying the best natural nitric oxide supplement, it is always better to check whether the ingredients are scientifically backed to ensure it’s safe and effective, having the minimum risk of adverse effects. Hence, those dietary supplements can be used confidently and without fear.

Efficiency In Improving Nitric Oxide Levels

Our marketplace is jam-packed with various best nitric oxide supplements. Hence, there is a high chance that we might get confused about which one to choose.

The best nitric oxide supplement is the one that boosts optimum NO production. So, we can get all the other health benefits, such as healthy blood pressure, free of cardiovascular disease, controlled blood sugar, and more.

Clinically Proven Dosage

The best nitric oxide supplements are always guarded with clinical trials and tests. It ensures that the users consume a supplement in the correct dosages to prevent any adverse effects.

Our list of top nitric oxide supplements contains only those products packed with active ingredients in the correct amounts. Too much nitrate supplementation in our diet can lead to unwanted toxicity and side effects.

User Convenience

When choosing a nitric oxide supplement, it is essential to consider ease of use. Since most nitric oxide booster-producing companies recommend using their supplement regularly to attain long-lasting results, user convenience and enjoyment should always be taken care of.

An easy-to-use nitric oxide supplementation having good flavor can be easily implemented in our daily lifestyle, leading to potential benefits and better compliance.

Cardiologist or Medical Professional Formulation

Medical professionals and cardiologists who know this field can understand the potential health effects of a specific ingredient. Hence, it is vital to choose a dietary nitrate supplementation that claims to be made under the guidance of medical professionals.

These medical professionals know the working mechanism of nitric oxide and the science behind it. So, they are the best people who can create an amino-acid-rich nitric oxide supplement having potential benefits.

Money-Back Guarantee And Cost Of Nitric Oxide Supplements

As we already know how the market sells different kinds of nitric oxide supplements, and they are made for various purposes. So, it is highly likely that one supplement might work for an individual while another might not. That’s why a money-back guarantee is essential apart from nitric oxide supplements cost.

We can buy the best budget nitric oxide supplement, try it for a few weeks, and see whether it has improved our body’s blood flow, blood pressure, or cardiovascular health. If not, we can quickly return it and claim a refund.

Does Science Back The Ingredients In The Best Nitric Oxide Boosters?

The best supplements often use clinically-proven ingredients that work with biological processes to enhance nitric oxide production to increase NO production.

Some of these ingredients have been mentioned below, along with the scientific evidence backing them:

L-Arginine Nitrate

L-arginine nitrate boosts NO levels by enhancing the expression of NOS. L-arginine nitrate has been shown to increase the expression of NOS in endothelial cells, which are responsible for producing NO in the body.

This increased expression of NOS increases NO production, leading to improved cardiovascular health and other physiological functions.

It is also better than several other amino acids at boosting NO levels in the body due to its ability to stimulate growth hormone release. L-arginine nitrate has been shown to stimulate growth hormone release, increasing nitric oxide production and improving cardiovascular health.

Stearic Acid

Stearic acid is a saturated fatty acid in animal and vegetable fats. It is also a natural component of human skin oils and is essential for maintaining healthy skin.

Stearic acid has been found to promote nitric oxide production. A study published in the Journal of Nutritional Biochemistry found that stearic acid supplementation helped increase nitric oxide levels in the blood of rats. The researchers concluded that stearic acid could be a potential dietary supplement for promoting nitric oxide production.

Grape Seed Extract

A 2013 study published in Cardiovascular Pharmacology investigated the effects of grape seed extract on nitric oxide levels in the body. The study involved 29 healthy adults randomly assigned to receive either a grape seed extract supplement or a placebo for six weeks.

The study results showed that the participants who took the grape seed extract supplement had significantly higher levels of nitric oxide in their blood than those who took the placebo. The researchers concluded that grape seed extract could effectively increase nitric oxide levels in the body, which may benefit cardiovascular health.


The high levels of dietary nitrate found in beetroot are converted into nitrite indirectly by enzymes called “nitrate reductase,” which can be found both in saliva and within the cells that line the stomach walls. This conversion occurs several times within the body as nitrite molecules change to ammonia, then back to nitrite, and eventually turn into nitric oxide. This can allow beetroot to offer numerous health benefits, including increasing athletic performance and muscle mass.

In addition to improving athletic performance and cardiovascular health, beetroot has further health benefits, such as protecting against oxidative stress due to its powerful antioxidant content.

Studies have found that regular consumption of beetroot can help protect against liver damage caused by toxins like alcohol or heavy metals; beetroot may even reduce cholesterol levels from dieting!

Vitamin C

Vitamin C plays a crucial role in nitric oxide production by acting as a cofactor for the enzyme nitric oxide synthase (NOS). NOS is responsible for converting the amino acid L-arginine into nitric oxide. Vitamin C helps to increase the activity of NOS by donating electrons to the enzyme, which enhances its ability to produce nitric oxide.

Vitamin C helps increase nitric oxide bioavailability by enhancing its stability. Nitric oxide is a volatile molecule that can break down quickly, limiting its effectiveness.

Vitamin C helps to stabilize nitric oxide by converting it into a more stable form called nitrite. Nitrite can then be converted back into nitric oxide when needed, providing a sustained increase in nitric oxide production.


Coffeeberry contains a high concentration of chlorogenic acid, a potent antioxidant that promotes NO levels in the body.

Its ability to promote NO levels in the body can also aid muscle performance in various ways. Firstly, increased NO levels can improve blood flow and oxygen delivery to the muscles, enhancing muscle performance and reducing fatigue during exercise.

Secondly, NO has been found to increase glucose uptake in the muscles, improving energy production during exercise and reducing the risk of muscle fatigue.

Pine Bark Extract

Unlike many ingredients, pine bark extract can promote NO levels in the body, independent of eNOS activation. One such mechanism is the inhibition of arginase, an enzyme that breaks down the amino acid arginine, a precursor to NO. Pine bark extract can increase arginine availability for eNOS to produce NO by inhibiting arginase.

Another mechanism by which it can promote NO levels is through the upregulation of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase. By upregulating these antioxidant enzymes, it can help to protect eNOS and maintain NO production.

Mango Fruit Powder

A study aimed to investigate the effects of mango fruit powder on NO levels in healthy adults. The study included 24 randomly assigned participants to consume 10 grams of mango fruit powder or a placebo for eight weeks.

The study showed that consuming mango fruit powder significantly increased NO levels in the body compared to the placebo group. The researchers also found that mango fruit powder consumption improved endothelial function, a critical factor in maintaining healthy blood vessels.


A study published in the Journal of Strength and Conditioning Research looked at the effects of L-citrulline supplementation on NO levels and physical performance in male athletes. The study involved 41 men randomly assigned to either a placebo group or a group receiving 8 grams of L-citrulline daily for six days.

The study results showed that the group receiving L-citrulline had significantly higher NO levels than the placebo group. Additionally, the L-citrulline group had improved physical performance, as measured by their ability to perform more repetitions during a bench press exercise.


Broccoli contains several bioactive compounds, including sulforaphane, glucoraphanin, and indole-3-carbinol. These compounds are known for their potent antioxidant and anti-inflammatory properties. Sulforaphane has been studied for its ability to increase nitric oxide levels.

A study published in the journal Clinical Nutrition Research investigated the effects of broccoli consumption on NO levels in the body. During the trial, it was revealed that the broccoli group had significantly higher NO levels than the control group. The researchers concluded that regular broccoli consumption may help increase nitric oxide levels in the body, which can have numerous health benefits.


What makes kale so valuable for nitric oxide boosters is its high concentration of nitrates. In addition to its high nitrate content, kale contains other active components that make it a powerful ingredient in nitric oxide boosters. Sulforaphane in kale has been shown to have anti-inflammatory properties and can help to reduce oxidative stress in the body.

Kale also contains kaempferol which can help improve endothelial function. This is important for maintaining healthy blood vessels and reducing the risk of cardiovascular disorders.

Lastly, kale is rich in fiber, which can help to regulate digestion and prevent constipation, allowing the body to better utilize the active components in nitric oxide boosters.

FAQs About Nitric Oxide and Supplementation

Q: Is Taking Nitric Oxide Supplements Safe?

A: While taking nitric oxide supplements is generally considered safe for most people, there are some potential risks. One of the main concerns is the possibility of interactions with other medications. Nitric oxide supplements can lower blood pressure, which can be dangerous for people already taking medication to lower their blood pressure.

Additionally, some people may experience side effects such as headaches, nausea, and stomach discomfort.

It’s important to remember that supplements are not regulated the same way as prescription drugs, so there is always a degree of uncertainty regarding their safety.

Q: What Is Nitric Oxide Synthase?

A: Nitric oxide synthase is an enzyme that catalyzes L-arginine conversion into NO. Nitric oxide is a gas produced by various cells in the body and is involved in many physiological processes, including regulating blood pressure, immune response, and neurotransmission.

There are three types of nitric oxide synthase: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). Each nitric oxide synthase type is found in different cells and tissues and is responsible for producing nitric oxide under specific conditions.

Q: What Are The Two Amino Acids Incorporated In Almost Every Best Nitric Oxide Pill?

A: In particular, two amino acids are incorporated in almost every best nitric oxide pill.

L-arginine is an amino acid essential for nitric oxide production. It is converted into NO through nitric oxide synthase (NOS). L-arginine helps to relax blood vessels and improve blood flow, which can increase oxygen and nutrient delivery to the muscles. This can lead to improved endurance, strength, and muscle recovery.

L-citrulline is another amino acid that is commonly found in nitric oxide supplements. It is converted into L-arginine, which can be used to yield nitric oxide. L-citrulline has been shown to improve blood flow and reduce fatigue during exercise. It can also help increase ATP production, the primary energy source for muscle cells.

Q: Can Increasing Nitric Oxide Production In The Body Be Associated With Risks?

A: While increasing nitric oxide production in the body can have potential benefits, it’s essential to be aware of its potential risks.

Even the best nitric oxide supplements or interventions may interact with blood thinners, diabetes medications, and erectile dysfunction drugs. For example, nitric oxide supplements may enhance blood thinner effects, increasing bleeding risk.

Some people may be allergic to NO supplements or interventions. Symptoms of an allergic reaction may include hives, itching, swelling, difficulty breathing, and chest pain. If you experience these symptoms after taking an NO supplement or intervention, seek medical attention immediately.

Before starting any new supplement or intervention, speak with a healthcare professional, and begin with a low dose to avoid potential side effects. As with any supplement or intervention, it’s essential to prioritize safety and listen to your body.

Q: Should You Opt For The Powder Form Of Nitric Oxide Supplement Or Pills?

A: Powder-form nitric oxide supplements are typically mixed with water or other liquids and consumed before a workout or physical activity. The powder form allows for customization of the dosage and can be adjusted to suit individual needs. The powder form absorbs faster into the bloodstream, providing a quicker onset of the supplement’s benefits.

Pill-form nitric oxide supplements, on the other hand, are convenient and easy to consume, making them a popular choice for those on the go. The dosage is predetermined, making it easier to keep track of how much you are consuming.

The pill form also eliminates the need for mixing with liquids, making it more accessible for those who don’t enjoy the taste of the powder form.

Q: What Is The Average Cost Of A Good Nitric Oxide Supplement?

A: The cost of nitric oxide supplements can vary depending on brand, ingredients, and dosage. On average, a good quality nitric oxide supplement can cost anywhere between $30 to $60 for a 30-day supply. However, some premium brands can charge upwards of $100 for a 30-day supply.

Notably, the price should not be the only factor to consider when purchasing a nitric oxide supplement. The ingredient quality and dosage are also crucial to consider.

Cheaper supplements may contain lower-quality ingredients, which can be less effective and even harmful to your health. On the other hand, premium supplements may have higher quality ingredients, which can be more effective, but may not be affordable for everyone.

The Top Best Nitric Oxide Supplements To Improve Blood Flow Final Verdict

After reviewing the many nitric oxide supplements, we have concluded that these supplements are worth the effort and money. Nitric oxide supplements provide healthy nitric oxide levels in our body and help expand blood vessels.

Moreover, Nitric Oxide supplements work to improve cardiovascular health and heart health as well as boost our immune system.

As with any dietary supplement, we recommend our readers consult a healthcare professional before taking nitric oxide supplements if they already have a pre-medical condition.

Related: Best Heart Health Supplements – Healthy Cardiovascular Support

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