NMN supplements are arguably the best NAD boosters available right now. If you’ve landed on this article, you’re probably clued up on the benefits of NMN in relation to anti-aging research.
This has sparked a flurry of interest in NMN supplements and with so many different brands on the market, it can be hard to know which ones are worth investing in.
The best NMN supplements will:
- Contain >98% purity NMN
- Not contain fillers or additives
- Be made by a reputable manufacturer in an FDA and GMP-registered facility
- Be 3rd party tested to confirm purity
With this in mind, here are the top NMN brands available right now
OMRE
OMRE is a premium supplement containing 98% purity NMN at a 500mg dose. It also contains 500mg of 98% Resveratrol which is another top anti-aging ingredient. These ingredients are arguably the two best-known molecules in aging research.
OMRE combines them together so you can get the benefits of both in a single product. This reduces the number of pills you have to take and makes it more cost-effective.
In terms of quality, OMRE ticks all the boxes because it doesn’t contain any additives and is made right here in the USA. Better still, it’s also sent for 3rd party testing for added reassurance.
Product highlights:
- No magnesium stearate or fillers
- Made in the USA in GMP certified facility
- Vegan capsule
- 3rd party tested
- Also includes 98% Resveratrol and Bioperine
Learn more on their website
Toniiq Elixir
Toniiq Elixir is another high-quality combination NMN supplement. With added Resveratrol and Betaine anhydrous, it covers all angles by providing a supplement that is designed for those who are serious about cellular aging. All ingredients are included at a solid dose of 500mg so you’re getting bang for your back.
They use veggie capsules and their supplement is also 3rd party tested.
Product highlights:
- Vegan capsule
- 3rd party tested
- Also includes 98% Resveratrol and Betaine anhydrous
- Strong brand reputation
Learn more on their website
Renue By Science
Renue provides NMN in liposomal format for better absorption. They have a range of NMN forms including a gel, sublingual, and even an NMN product for your pets!
All their supplements are 3rd party tested and allergen-free.
Product highlights:
- Lipo NMN
- 3rd party tested
- Offer a whole range of NMN forms that are optimally absorbed
- Lots of experience in longevity products
Learn more on their website
Nadiol
Nadiol is a UK based company that provides a range of NMN powders and pills at >99%. Their NMN products are Non-GMO, Gluten-free, and Vegan friendly. Additionally, they are also suppliers of bulk NMN for others to sell.
Product highlights:
- Experts in powdered NMN
- Ship worldwide
- Money-back guarantee
Learn more on their website
ProHealth Longevity
ProHealth claims to provide the highest purity NMN in the world, featuring Uthever NMN which is ultra-high purity at over 99%. This NMN brand has been around since 1988 and they are experts in longevity supplements.
Their site contains an abundance of various forms and doses of NMN so you can choose what is best for you based on your goals.
Product highlights:
- Lots of experience
- Range of forms and doses
- Uthever NMN
Learn more on their website
Youth & Earth
Youth & Earth is one of the best-known British NMN brands. All their NAD boosters are 3rd party tested and they provide certificates on their online store. They offer big multi-order discounts and are good value for money.
Product highlights:
- British brand
- Offer a range of NAD boosters other than NMN
- Multi-pack discounts
Learn more on their website
Genex Formulas
Genex is another popular NMN brand that has its supplements manufactured in the USA, in a GMP certified facility. Their products are free from allergens and do not contain magnesium stearate or silicon dioxide. They also sell other longevity supplements like Resveratrol and Quercetin.
Product highlights:
- Made in the USA
- Offer a range of longevity supplements
- No magnesium stearate or silicon dioxide
Learn more on their website
What to look for when buying NMN supplements?
In your search for the best NMN supplement, there are really only a few things you need to know about. There’s a lot of marketing jargon that can add to the confusion. But here are the factors that really matter:
Purity and dose
Maximum purity is key when it comes to NMN supplements. The best NMN brands use 98% purity or above.
The next thing to consider is the dose. Now, there is no official recommended dose so you will ultimately have to decide what’s best for yourself. Most NMN supplements will contain anywhere from 200mg to 1000mg of NMN.
A higher dose isn’t necessarily better. So if you’re just starting out, you may want to consider a smaller dose to see how you get on.
Additives
When supplements are made, large machinery is used to pack the pills with ingredients. To prevent the machinery from clogging up, inactive ingredients are added to smooth out the process. These additives are called ‘flow agents’.
For decades the main flow agents used are silicon dioxide and magnesium stearate. Premium supplements use vegan alternatives such as rice flour.
Manufacturing standards
You’ll want to go with a brand that has its supplement manufactured in a GMP-certified facility. This stands for good manufacturing practice and the name really explains itself. Manufacturers in the US and Europe will often have these credentials as a minimum.
Some manufacturers send their products for 3rd party testing as well. This is an additional layer of checks to ensure the pills don’t contain any unwanted ingredients, heavy metals, or bacteria. It can also ensure the purity and accuracy of the ingredient doses.
Other ingredients
NMN is arguably the hottest anti-aging ingredient around at the moment. However, there are many other ingredients that have also been studied and shown to have great promise in the anti-aging arena.
These include Quercetin, Fisetin, Resveratrol, and spermidine. And more are being identified all the time.
Although NMN is the frontrunner, these other ingredients work in different ways and are still important. So the best NMN supplements combine some of them to create a more powerful overall anti-aging blend.
What are NMN supplements good for?
NMN supplements are often marketed as anti-aging supplements with the ambition of improving various aspects of health, including energy production, metabolism, and cognitive function. NMN, which is short for (nicotinamide mononucleotide), is a precursor to the coenzyme NAD+, which plays a key role in various cellular processes, including energy production, DNA repair, and gene expression. In other words, NAD+ is critical for normal cellular function.
NAD+ levels start to decline with age. In fact, by the time you’re in your 30s, NAD+ levels have already dropped to half the levels they were when you were a teenager.
Some studies have suggested that NMN supplementation can increase NAD+ levels in the body, which may provide various health benefits, such as:
- Improved metabolism: NMN may increase insulin sensitivity, improve glucose tolerance, and promote fat metabolism, which may be beneficial for weight management and reducing the risk of type 2 diabetes.
- Improved cardiovascular health: NMN may improve blood vessel function and reduce inflammation, which may lower the risk of cardiovascular diseases.
- Anti-aging effects: NMN may help repair damaged DNA and increase cellular energy production, which may slow down the aging process and reduce the risk of age-related diseases. (1)
However, it is important to mention again that most of the studies on NMN supplements have been conducted in animals or small human studies. So although there’s a lot of hope in NMN, a lot more research needs to be done. It is also important to consult with a healthcare professional before starting any new supplement regimen.
Is NMN just vitamin B?
NMN is a derivative of vitamin B3, also known as niacin or nicotinamide, but it is not the same thing as vitamin B3. NMN is a molecule that is synthesized from vitamin B3 within the body and is a precursor to the coenzyme nicotinamide adenine dinucleotide (NAD+), which plays a key role in various cellular processes, including energy production, DNA repair, and gene expression.
While both vitamin B3 and NMN are involved in the production of NAD+, NMN is more readily absorbed by the body and is considered a more efficient way to increase NAD+ levels compared to vitamin B3. NMN is also more stable than vitamin B3 and less likely to cause the flushing effect, a side effect commonly associated with high doses of vitamin B3.
How long does it take for NMN supplements to start working?
There are a handful of NMN studies that have shown that NAD+ levels start to rise relatively soon after taking NMN supplements. (2)
Some studies have shown that blood levels of NAD+ rise within a matter of 2-3 weeks. But how this correlates to observable health benefits is not yet known.
In other words, it could take several months of consistent NMN supplementation before any noticeable benefits are seen.
If NMN supplements are ultimately shown to improve health, it’s likely that it will be seen at a cellular level with tests showing improvement in blood biomarkers to determine biological age. These tests look at the level of chronic inflammation as well as glycated blood levels.
Anecdotally, people report feeling that they have more energy or better skin. But most people may not necessarily feel much different in the short term.
At what age should you start taking NMN supplements?
The optimal age to start taking NMN supplements is currently unclear and still an area of active research. It ultimately comes down to personal preference.
At present, there is no consensus on the age at which individuals should start taking NMN supplements. Some researchers have suggested that individuals may start to experience a decline in NAD+ levels as early as their 20s, while others believe that the decline may not become significant until later in life.
Some scientists argue that if NAD+ levels start to drop significantly by the time we are adults, it may be best to start sooner rather than later.
What time of day should you take NMN supplements?
NMN supplements are best taken with a meal to aid in absorption and reduce the risk of digestive issues. Some scientists suggest that taking NMN supplements in the morning may be more effective since NAD+ levels tend to decline throughout the day. This way, you are boosting NAD+ levels in line with your natural body clock.
What are the dangers of taking NMN supplements?
NMN supplements are generally considered safe, and at the time of writing, there have been no reports of serious adverse effects in humans. However, there is still limited research on the long-term safety of NMN supplementation in humans, and some potential risks and side effects may include:
- Gastrointestinal issues: Some people may experience digestive issues, such as nausea, diarrhea, or bloating, when taking NMN supplements.
- Interactions with medications: NMN may interact with certain medications, such as blood thinners, diabetes medications, or immunosuppressants, and it is important to consult with a healthcare professional before taking NMN supplements if you are taking any medications.
- Unknown long-term risks: Since NMN supplements are relatively new, there is limited research on the long-term safety of taking NMN supplements in humans, and there may be unknown risks associated with long-term use.
Given that NMN is something we all naturally produce in our body from vitamin B3, it’s generally well tolerated. If people do experience negative side effects, it’s usually because of other ingredients such as magnesium stearate or silicon dioxide which are added during the manufacturing process.
The main consideration is the long term effect of taking high doses of NMN. We won’t know the answer to this for at least a few years.
Which NMN supplement does David Sinclair take?
David Sinclair, a prominent aging researcher and Harvard Medical School professor, has mentioned in interviews and social media posts that he takes a NMN supplement. However, he has not publicly disclosed the specific brand or product he takes.
He does say that he takes 1000mg of NMN a day, along with Resveratrol. In addition, he has added fisetin and Quercetin to his routine which are other anti-aging molecules.
Can you take NMN supplements with Resveratrol?
Yes, it is generally safe to take NMN supplements with resveratrol. In fact, some people take both supplements together as they believe they may work synergistically to promote health and longevity.
As mentioned, NMN is a precursor to NAD+. Whereas, Resveratrol is a natural compound found in red wine, grapes, and some berries, and has been shown to activate sirtuins, a class of proteins that help regulate cellular processes related to aging and stress resistance.
In simple terms, Resveratrol also increases NAD+ levels but via different pathways.
What is the best form of NMN supplement to take?
There are several forms of NMN supplements available, including capsules, powders, and sublingual tablets. However, there is no one “best” form of NMN that works for everyone. The choice of NMN supplement form may depend on individual preferences and factors such as convenience, absorption, and dosage.
Capsules are a convenient and easy-to-take form of NMN, but their absorption rate may vary depending on the individual’s digestive system. Powders may provide more flexibility in dosage and can be mixed with drinks or food, but they may have a slightly bitter taste.
Sublingual tablets are designed to dissolve under the tongue and may have higher absorption rates than other forms of NMN due to bypassing the digestive system. However, they may be less convenient to use, and some people may not like the taste or texture of sublingual tablets.
At the end of the day, it comes down to your own preference!
FAQs
Does NMN make you look younger?
Although NMN is a so-called anti-aging supplement, there is currently no evidence to suggest that taking NMN can directly make a person look younger. People often say they feel their skin has become smoother, but this could be a placebo effect.
Also, the biggest factor in skin aging is sun exposure. UV radiation is the fastest way to age your skin so the best way to look younger for longer is to use high factor sun cream and avoid using sun beds.
Why does NMN cost so much?
One of the most noticeable things about NMN is its price point. The best NMN supplements are often premium priced because the raw ingredient is much more expensive compared to other micronutrients.
The reason is, the production of NMN is a complex process that requires advanced technology and expertise. NMN is synthesized through a multi-step process that involves several chemical reactions and requires high purity levels to ensure safety and efficacy. The cost of producing high-quality NMN can be significant, which is reflected in the price of NMN supplements.
Can you get NMN naturally?
NMN can also be found naturally in some foods, although the amount of NMN in these foods is tiny compared to that in supplements. Some dietary sources of NMN include:
- Edamame
- Broccoli
- Cucumber
- Avocado
- Tomato
- Raw beef
However, it is important to note that the amount of NMN in these foods is relatively small and may not be sufficient to significantly increase NAD levels in the body. Additionally, cooking and processing of these foods may decrease the amount of NMN they contain.
Do NMN supplements cause weight gain?
There is currently no evidence to suggest that NMN supplements cause weight gain. In fact, some studies suggest that NMN may actually have the opposite effect and could potentially help with weight management.
One study conducted on mice found that NMN supplementation led to an increase in energy expenditure and a decrease in body weight and fat mass, possibly due to the activation of a metabolic pathway called SIRT1. Another study in humans found that NMN supplementation improved insulin sensitivity and glucose metabolism, which are important factors for maintaining a healthy weight.
Does NMN affect sleep?
There is limited research on the effects of NMN supplementation on sleep. However, some studies suggest that NMN may have positive effects on sleep quality.
One study conducted on mice found that NMN supplementation increased NAD+ levels in the brain, which led to improved sleep quality and reduced sleep fragmentation. Another study in humans found that NMN supplementation improved circadian rhythm function, which could potentially have positive effects on sleep quality.
Can I take NMN with coffee?
There is no issue with taking NMN supplements with your morning coffee. They do not interact with each other and it is generally considered safe to take NMN with coffee.
How else can I increase NAD+ levels?
Aside from taking NMN supplements, there are several natural ways to boost NAD+ levels in the body:
- Eating a healthy and balanced diet: Consuming a diet rich in foods such as lean proteins, vegetables, fruits, nuts, and whole grains can help to support NAD+ levels.
- Exercise regularly: Regular physical activity can help to increase NAD+ levels by
stimulating the production of a protein called PGC-1 alpha, which is involved in energy metabolism. - Fasting: Fasting has been shown to increase NAD+ levels in the body. Intermittent fasting or time-restricted eating can also be effective.
- Reducing stress: Chronic stress can deplete NAD+ levels, so reducing stress through activities such as meditation or yoga may help to support NAD+ levels.
- Getting enough sleep: Sleep is essential for cellular repair and can also help to support NAD+ levels in the body.
Which is better, NMN or NR?
NMN and NR (nicotinamide riboside) are both precursors to NAD+ and are believed to be effective at boosting NAD+ levels in the body. However, there is an ongoing debate about which one is better.
NMN is a more direct precursor to NAD+ than NR, and some research suggests that it may be more effective at boosting NAD+ levels.
In our cells, NR is converted to NMN before it’s converted to NAD+. That’s why scientists believe that NMN is the fastest and most efficient route to NAD+ production.
On the other hand, supporters of NR argue that NMN is a larger molecule and less easily absorbed into the bloodstream when taken as a supplement. However, more recent research has shown that NMN is readily absorbed from the gut.
What is the best dose of NMN to take?
This depends on your personal goals and the best dose will be different for everyone. On top of this, there is no official recommended dose because research is still ongoing.
Most studies use a range of 200mg to 1000mg and that’s why you’ll see that most NMN supplements provide a dose in this range.
The top NMN brands usually include around 500mg of NMN which is a good middle ground.
Is it OK to take NMN supplements everyday?
It is generally considered safe to take NMN supplements every day. However, the optimal dosage and frequency of NMN supplements can vary depending on a number of factors, including your age, health status, and individual needs.
It’s also worth noting that the long-term effects of taking NMN supplements every day are not yet fully understood, as research on this is still ongoing.
At the time of writing, there are a few human studies that have given trialed NMN supplements as high as 900mg a day for 60-90 days with no reported problems. (3)
What happens when you stop taking NMN supplements?
If you stop taking NMN supplements, the levels of NMN in your body will eventually return to their baseline levels. However, the speed at which this occurs will depend on several factors, including your age, overall health, and individual metabolic rate.
There are no withdrawal effects when you stop taking NMN supplements and you can do so whenever you wish.
How do I know if NMN is working?
The best way to tell if the NMN supplements you are taking are working is to do biological age testing which requires blood tests and can be quite expensive.
There are a few other potential indicators that NMN may be working:
- Increased energy: Some people report feeling more energetic and alert after taking NMN supplements.
- Improved physical performance: NMN may improve physical performance by increasing endurance and reducing fatigue during exercise.
- Improved cognitive function: NMN may improve cognitive function and memory, especially in older adults.
- Improved skin health: Some people report improvements in skin health, including increased elasticity and reduced wrinkles.
- Improved metabolism: NMN may improve metabolic function by increasing insulin sensitivity and reducing inflammation.
But for most people, you won’t notice much difference in the short term.
Best NMN supplements – Conclusion
That concludes our review of the best NMN supplements on the market right now.
When you strip back the packaging and branding, the only thing that really matters is the quality of NMN. Look out for high-purity NMN that’s been manufactured in a region with high standards. The best NMN brands will also send their product for 3rd party testing which is an additional layer of reassurance.
There’s a huge amount of interest in NMN supplements at the moment but it’s important to note that most of the studies on NMN supplements have been conducted in animals or small human studies, and more research is needed to determine the long-term safety and effectiveness of NMN supplementation in humans.
But if you’re keen to start taking NMN, the top NMN brands reviewed in this article are all good options.