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The title of Mike Mills’ documentary is derived from the ad campaign mounted by Glaxo­SmithKline in 2000, when it became the first company to market antidepressants in Japan. The implication is that big pharma invented not just a market but also an illness when it began advertising chemical balms for utsu, the new Japanese term for depression. But the film doesn’t really pursue this analysis, settling instead for an easy strategy of observing four young Tokyo residents who use Paxil or similar drugs. One of them is Taketoshi, a gay masochist who wanders the streets in short-shorts and high heels and is sometimes pummeled on stage at S&M clubs. His eccentric story overwhelms the other three and stretches the definition of “depression.” (Taketoshi surely wasn’t Glaxo’s intended consumer.) The filmmakers fill the rest of this lackadaisical study with the usual views of trains, neon, and crowds and hang around Shibuya as if waiting for Scarlett Johansson to show up. There’s material here for an insightful study, but this movie is so flimsy, it’s almost depressing.