Tim Heidecker and Eric Wareheim, the creators of Adult Swim’s live-action show Tim and Eric Awesome Show, Great Job!, are about to find out if they have an audience beyond late-night Cheeto-eaters. The show, which kicks off its fourth season with a national tour, contains the expected fake infomercials and tawdry music videos. But the core of its artful awkwardness is its use of earnest, ordinary-looking folks, most of whom Wareheim and Heidecker recruited off the streets of Los Angeles and through Craigslist ads. The show also features cameos from John C. Reilly, who plays a socially incompetent, wild-haired local TV-news personality named Dr. Steve Brule. In a segment for stomach-doubling, where a synthetic pouch is surgically inserted to act as a reservoir for “the bad food,” Reilly proclaims, “I love to eat bad foods for me. But I don’t wanna get fat like a tub of lard. This is like a summer house for your body.” The performance, featuring guests James Quall and David Liebe Hart, will re-create sketches, but there’ll be tour-only material, too, taking the show’s passion for all things nonsequitorial to all new heights.

TIM AND ERIC PERFORM AT 8 P.M. AT SIXTH AND I HISTORIC SYNAGOGUE, 600 I ST. NW. $25. (202) 408-3100.