When it comes to physical humor, it’s hard to upstage the Brits on their own turf. They’ve made pratfalls and spit-takes their comedic bread and butter since the days of John Cleese’s silly walks. But that’s exactly what the Pajama Men—Shenoah Allen and Mark Chavez—have been doing for the past several years. Natives of Albuquerque, they’ve been assaulting each other on stage since meeting as high school students in 1993. What they do can’t be described by just one comedy genre—part pantomime, part musical revue, part slapstick, most of it improvised—but by God, it is popular. They were named best double act at the Edinburgh Fringe Festival in 2005, and since then, they’ve toured the world in their best flannel jammies, cracking jokes and selling out runs from Sydney to Chicago. Their newest production, In the Middle of No One, rolls all the elements of their comedy into a romantic thriller about alien abduction. It begins its run at Woolly Mammoth this week. Just try to make sense of it.

The production runs to Jan. 6 at Woolly Mammoth Theatre Company, 641 D St. NW. $35-$55. (202) 393-3939. woollymammoth.net