When she debuted in the mid-1990s, Maria Bamford stood out for two reasons: her high-pitched voice and her creepy ability to impersonate different types of women. Since then, she’s gained fame as one of the “Comedians of Comedy,” but her increasing popularity has not made her work any less challenging. Lately Bamford is more interested in frail sanity, her loneliness, and her battle with depression. Because she’s such a gifted comedian, she handles these serious topics with a light touch and deep intelligence; there are moments during her sets where she’s several steps ahead of her audience. Bamford is an atheist, so a synagogue may not make her feel comfortable, exactly, but the venue is certainly an improvement over her latest special, when she performed in her parents’ living room.